Professor David Y.H. Pui (University of Minnesota) et al. recently published a journal article entitled, “Recirculating Air Filtration Significantly Reduces Exposure to Airborne Nanoparticles.” The article characterizes the reduction of nanoparticle number concentrations when using the recirculation mode of the ventilation system in a Saab 93 (2003 model) and a Toyota Camry (2007 model). In simulated heavy-traffic situations, where particle number concentrations can be greater than 50,000 particles/cubic centimeter (cc) for particle diameters less than 50 nanometers (nm), the authors determined that setting the cars’ air ventilation systems in recirculation mode can decrease the number concentrations to background levels of less than 4000 particles/cc in approximately 3 minutes (1, 2).
Nanoparticle and Ultrafine Particle Jargon
By definition, ‘nano’ is one-billionth of a meter. A strand of human hair, for example, is approximately 70,000 nm (70 microns) and a water molecule is about one-third of a nanometer (0.3 nm).
Companies are constantly finding new ways to incorporate nanomaterials in products to improve design and cost effectiveness. New methods for manufacturing and handling nanomaterials are constantly being discovered. In addition, exciting applications are being developed such as tumor detection and targeted nanoparticle delivery for cancer treatment along with nanoparticle-based pollution control and remediation (3, 4).
The definitions of nanoparticles (NPs) and ultrafine particles (UFPs) are closely related. Particles can be referred to as a NPs if one of their dimensions is less than 100 nm, while UFPs are defined as particles which are less than 100 nm (0.1 microns) in all dimensions (4, 5).
UFPs are considered to be generated unintentionally and are not engineered to any great extent. On the other hand, NPs are the engineered building blocks of nanomaterials such as carbon nano-tubes (CNTs) (5, 6).
Health Effects
There are ongoing discussions in medical, public health, and scientific fields concerning the human health effects of inhaled nanomaterials. The short- and long-term toxic effects of human exposure to inhaled nanoparticles are unknown (6, 7).
The pulmonary toxicity of UFPs has been demonstrated in controlled laboratory experiments (8-10). In addition, studies continue to link environmental exposure to fine particles less than 2.5 μm in size to adverse health effects, such as respiratory irritation, reduced lung function, and associated cardiopulmonary impairment (11-13).
UFPs are widespread in the urban atmosphere because they are predominantly produced from the combustion of fossil fuels. If you are in the vicinity of an automobile, commercial truck, power plant, or oil-burning furnace, you are likely exposed to nanoparticles in varying concentrations. In general, the reported health effects from fine particulate matter air pollution are dependent upon the exposure concentration and the length of exposure (13).
Recirculation Mode ON? Check.
When I drive in the city I often use the air recirculation option of my car’s ventilation system. This means that, neglecting outside air infiltration, no outside, unfiltered air is entering the cabin and the cabin air is being recirculated through the ventilation system. In newer cars, the air may pass through the cabin air filter repeatedly in this recirculation mode.
One-hundred percent of new cars in Europe and Japan and more than 60% of new American cars have cabin air filters. Pui et al. mentions that there has been no systematic study showing the filtration efficiency of automobile cabin air filters for particles less than 300 nm. The study demonstrated that the cabin air filters were relatively inefficient when compared to the high efficiency particulate air (HEPA) filters. However, tests conducted with and without the cabin air filter in the recirculation loop of the Toyota Camry (2007 model) showed significant reductions in UFP number concentrations for the filtered case. Therefore, even with a relatively inefficient cabin air filter, the recirculation mode can significantly reduce exposure to UFPs.
Particle diffusion is the main mechanism of removal for particles in the size range of 10-100 nm. This means that UFPs are removed in the recirculation mode by filtration and deposition on the ventilation system walls and fan. Generally, if particles in 10-100 nanometer size range are given enough time to diffuse to available surfaces, a decrease in number concentrations will be observed.
After seeing the effect of the recirculation mode quantified, you can bet that I will keep the recirculation option on during high-, slow-, stalled-traffic occurrences. Finally, although there currently isn’t a standard to determine nanoparticle filtration efficiency of automobile cabin air filters, they are still likely to reduce nanoparticle number concentrations and exposure.
1. D. Y. H. Pui, C. Qi, N. Stanley, G. Oberdörster, A. Maynard. Recirculating Air Filtration Significantly Reduces Exposure to Airborne Nanoparticles. Environmental Health Perspectives 116, 863 (2008).
2. D. B. Kittelson, W. F. Watts, J. P. Johnson. Nanoparticle emissions on Minnesota highways. Atmospheric Environment 38, 9 (2004).
3. S. Azarmi, W. H. Roa, R. Löbenberg. Targeted delivery of nanoparticles for the treatment of lung diseases. Advanced Drug Delivery Reviews (2008).
4. P. Biswas, C. Y. Wu. Nanoparticles and the environment. Journal of the Air & Waste Management Association 55, 708 (2005).
5. K. Donaldson et al. Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Particle and Fibre Toxicology 2, 10 (2005).
6. M. R. Gwinn, V. Vallyathan. Nanoparticles: Health Effects—Pros and Cons. Environmental Health Perspectives 114, 1818 (2006).
7. W. Yang, J. I. Peters, R. O. Williams. Inhaled nanoparticles—A current review. International Journal of Pharmaceutics 356, 239 (2008).
8. A. Nemmar et al. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. American Journal of Respiratory and Critical Care Medicine 164, 1665 (2001).
9. A. Nemmar et al. Passage of inhaled particles into the blood circulation in humans. Circulation 105, 411 (2002).
10. G. Oberdorster et al. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. Journal of Toxicology and Environmental Health-Part A 65, 1531 (2002).
11. M. Brauer et al. Air pollution and retained particles in the lung. Environmental Health Perspectives 109, 1039 (2001).
12. R. D. Brook et al. Air pollution and cardiovascular disease – A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 109, 2655 (2004).
13. C. A. Pope III, D. W. Dockery. Health Effects of Fine Particulate Air Pollution: Lines that Connect. Journal of the Air & Waste Management Association 56, 709 (2006).